Kinetic Resolution of Primary Amines via Enantioselective N-Acylation with Acyl Chlorides in the Presence of Supramolecular Cyclodextrin Nanocapsules

• Asahara, Haruyasu

• Kida, Toshiyuki

• Iwamoto, Takuya

• Hinoue, Tomoaki

• Akashi, Mitsuru

Abstract

The non-enzymatic kinetic resolution of primary amines via enantioselective N-acylation with acyl chlorides was accomplished for the first time by using the selective sequestration of one enantiomer within a supramolecular cyclodextrin (CD) nanocapsule in nonpolar solvents. In addition, the first example of a crystalline structure for an inclusion complex between an acyl chloride and a CD derivative is reported.

Journal

• Tetrahedron

  Tetrahedron 70 (2), 197-203, 2014

  Elsevier Ltd.

Keywords

• Organic Chemistry
• Drug Discovery
• Biochemistry

Details

• CRID: 1050282676662523776
• NII Article ID: 120005728983
• DOI: 10.1016/j.tet.2013.11.097
• ISSN: 00404020
• Web Site: http://hdl.handle.net/10173/1331
• Web Site: https://api.elsevier.com/content/article/PII:S0040402013018309?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0040402013018309?httpAccept=text/plain
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN