<研究論文>合成ノビレチンの経口投与によるラット真皮への影響

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  • ゴウセイ ノビレチン ノ ケイコウ トウヨ ニ ヨル ラット シンピ エ ノ エイキョウ
  • <Original Papers>Effects of orally administered synthetic nobiletin on rat dermis

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Abstract

[Abstract] Shiikuwasha (Citrus depressa Hayata), a typical Japanese citrus fruit, recently has been expected to make the healthy skin. Nobiletin (5, 6, 7, 8, 3', 4'-hexamethoxy flavone), a citrus polymethoxy flavonoid, is one of the compounds of Shiikuwasha. Nobiletin has been reported in in vitro studies that it possesses various bioactive effects, such as anti-inflammatory activities, however, few in vivo studies have been done. In this study, we examined the effects of nobiletin involved in the impact on the collagenolysis. We revealed that nobiletin increases mRNA expressions of anti-oxidant enzymes. Furthermore, nobiletin suppresses mRNA expressions of matrix metalloproteinases (MMPs) and increases mRNA expressions of peroxisome proliferator activated receptors (PPARs). These results suggest that anti-oxidative action and suppression of the collagenolysis in the dermis may be enhanced through the oral administration of nobiletin.

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