Effect of lipids on the direct absorption of methyl mercury by lymph and blood

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[Abstract] We previously reported that mercury was absorbed not only into the portal vein but　also into lymph after methyl mercury was infused into the intestine (Murota et al., 2012). Although methyl mercury mixed with saline was administered to rats in the previous report, it is known that methyl mercury is contained in fish and seafood products and is taken up into the body in food. Therefore, the aim of the present study was to identify the effect of various lipids on the direct absorption of methyl mercury by blood and lymph. Methyl mercury was mixed with fish oil, lard, olive oil, soy oil,taurocholate, and saline. When methyl mercury mixed with lipids was administered to rats, the volume of lymph collected every 30 minutes did not differ between Saline and each lipid mixture group, except the Lard group at 90-120 minutes. Mercury concentration per 1 ml of lymph increased in the Fish oil group at 180-210 minutes and the Soy oil group at 270-300 minutes in comparison with the Saline group. However, when the amount of mercury in lymph collected in 30 minutes was calculated from the volume of lymph, there was no difference among groups at all collection times. In addition, the cumulative mercury amount in lymph did not differ among groups at all collection times. Furthermore, there was no difference in blood mercury concentration among groups at all collection times. From the present results, it is concluded that the quantity of lymph and blood absorption of mercury does not differ even if methyl mercury is given with various lipids.

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