ネパールにおける遺伝性ヘモグロビンE(HbE)の解析

• 遠藤, 敏廉

• 池田, 美知代

• 佐藤, 慶子

• 立山, 涼子

• 濱野, 真二郎

• 服巻, 保幸

• 小林, 茂

Bibliographic Information

Other Title

• ネパール ニ オケル イデンセイ ヘモグロビン E HbE ノ カイセキ
• Analysis of hereditary hemoglobin E (HbE) in Nepal

Abstract

It has been suggested that a high frequency of abnormal hemoglobin might reflect an advantage due to a reduced susceptibility to malaria. To evaluate this malaria hypothesis, we analyzed abnormal hemoglobin in two neighboring populations of Nepal: the Danuwar and the Tamang. It was hypothesized that the settlements of the former were biologically adapted to the malarial environment, whereas those of the latter were customarily adapted. We detected nine heterozygotes for the β^E mutation generating HbE in four families in the Danuwar setllement by analysis of isoelectric focusing (IEF) and high performance liquid chromatography (HPLC).

Departmental Bulletin Paper

application/pdf

Journal

• Research bulletin of Kyushu Junior College of Kinki University

  Research bulletin of Kyushu Junior College of Kinki University 34 67-74, 2004-12-01

  近畿大学九州短期大学

Keywords

• HbE
• malaria
• HPLC
• IEF
• Nepal

Details

• CRID: 1050282677533997568
• NII Article ID: 120005737635
• NII Book ID: AN10297606
• ISSN: 09164383
• NDL BIB ID: 7257035
• Web Site: https://kindai.repo.nii.ac.jp/records/11685
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7257035
• Text Lang: ja
• Article Type: departmental bulletin paper
• Data Source:
  • IRDB
  • NDL
  • CiNii Articles
  • KAKEN