Inverse association of highly chlorinated dioxin congeners in maternal breast milk with dehydroepiandrosterone levels in three-year-old Vietnamese children

• Kido, Teruhiko

• Honma, Seijiro

• Nhu, Dang Duc

• Manh, Ho Dung

• Tung, Dao Van

• Liang, Sun Xian

• Anh, Le Thai

• Okamoto, Rie

• Maruzeni, Shoko

• Nakagawa, Hideaki

• Hung, Nguyen Ngoc

• Son, Le Ke

抄録

This study aims to evaluate the endocrine-disrupting effect of dioxin congeners on adrenal steroid hormones in mother-child pairs. In our previous study, we found that cortisol and cortisone levels were higher in the blood and the saliva of mothers living in a dioxin hotspot area than in mothers from a non-exposed region in Vietnam. In this follow-up study, we determined the salivary steroid hormone levels in 49 and 55 three-year-old children of these mothers in the hotspot and non-exposed region, respectively. Steroid hormones were determined by liquid chromatography-tandem mass spectrometry, and dioxin in the maternal breast milk was determined by gas chromatography-mass spectrometry. Dioxin levels in the breast milk of mothers from the hotspot (median total toxic equivalents polychlorinated dibenzodioxins/polychlorinated dibenzofurans; (TEQ PCDD/Fs) of 11. pg/g lipid) were three to four times higher than those of mothers in the non-exposed region (median TEQ PCDD/Fs of 3.07. pg/g lipid). Salivary dehydroepiandrosterone (DHEA) levels in children were found to be significantly lower in the hotspot than in the non-exposed region, while cortisol and cortisone levels were not different between the two regions. Highly chlorinated dioxin congeners, such as octacholorodibenzodioxin (OCDD), 1,2,3,4,6,7,8-heptacholorodibenzodioxin (HpCDD) and 1,2,3,4 (or 6), 7,8-hexachlorodibenzodioxin Hx(CDD), showed stronger inverse associations with the children's salivary DHEA than other lowly chlorinated dioxin congeners. Glucocorticoid levels in the mothers exhibited a significantly positive correlation with OCDD and HpCDD/F (polychlorinated dibenzofurans). In conclusion, highly chlorinated dioxin congeners are more strongly correlated with endocrine-disrupting effects on adrenal hormones, resulting in high cortisol levels in the mothers and low DHEA levels in their three-year-old children. © 2016 Elsevier B.V.

Embargo Period 24 months

収録刊行物

• Science of the Total Environment

  Science of the Total Environment 550 248-255, 2016-04-15

  Elsevier B.V.

キーワード

• Cortisol
• Dehydroepiandrosterone (DHEA)
• Dioxin
• Endocrine-disruption
• Vietnamese children

詳細情報

• CRID: 1050001335951066368
• NII論文ID: 120005743917
• NII書誌ID: AA00836666
• ISSN: 00489697
• Web Site: http://hdl.handle.net/2297/44882
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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