Insulin secretory defect and insulin resistance in isolated impaired fasting glucose and isolated impaired glucose tolerance

• Aoyama-Sasabe, Sae

• Fukushima, Mitsuo

• Xin, Xin

• Taniguchi, Ataru

• Nakai, Yoshikatsu

• Mitsui, Rie

• Takahashi, Yoshitaka

• Tsuji, Hideaki

• Yabe, Daisuke

• Yasuda, Koichiro

• Kurose, Takeshi

• Inagaki, Nobuya

• Seino, Yutaka

Abstract

Objective. To investigate the characteristics of isolated impaired glucose tolerance (IGT) and isolated impaired fasting glucose (IFG), we analyzed the factors responsible for elevation of 2-hour postchallenge plasma glucose (2 h PG) and fasting plasma glucose (FPG) levels. Methods. We investigated the relationship between 2 h PG and FPG levels who underwent 75 g OGTT in 5620 Japanese subjects at initial examination for medical check-up. We compared clinical characteristics between isolated IGT and isolated IFG and analyzed the relationships of 2 h PG and FPG with clinical characteristics, the indices of insulin secretory capacity, and insulin sensitivity. Results. In a comparison between isolated IGT and isolated IFG, insulinogenic index was lower in isolated IGT than that of isolated IFG (0.43 ± 0.34 versus 0.50 ± 0.47, resp.; p < 0.01). ISI composite was lower in isolated IFG than that of isolated IGT (6.87 ± 3.38 versus 7.98 ± 4.03, resp.; p < 0.0001). In isolated IGT group, insulinogenic index showed a significant correlation with 2 h PG (r = - 0.245, p < 0.0001) and had the strongest correlation with 2 h PG (β = - 0.290). In isolated IFG group, ISI composite showed a significant correlation with FPG (r = - 0.162, p < 0.0001) and had the strongest correlation with FPG (β = - 0.214). Conclusions. We have elucidated that decreased early-phase insulin secretion is the most important factor responsible for elevation of 2 h PG levels in isolated IGT subjects, and decreased insulin sensitivity is the most important factor responsible for elevation of FPG levels in isolated IFG subjects.

Journal

• Journal of Diabetes Research

  Journal of Diabetes Research 2016 2016

  Hindawi Publishing Corporation

Details

• CRID: 1050845760760143488
• NII Article ID: 120005745643
• ISSN: 23146753
• HANDLE: 2433/210249
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles