Amylose-Based Cationic Star Polymers for siRNA Delivery

• Nishimura, Tomoki

• Umezaki, Kaori

• 向井, 貞篤

• 澤田, 晋一

• 秋吉, 一成

抄録

A new siRNA delivery system using a cationic glyco-star polymer is described. Spermine-modified 8-arm amylose star polymer (with a degree of polymerization of approximately 60 per arm) was synthesized by chemoenzymatic methods. The cationic star polymer effectively bound to siRNA and formed spherical complexes with an average hydrodynamic diameter of 230 nm. The cationic 8-arm star polymer complexes showed superior cellular uptake characteristics and higher gene silencing effects than a cationic 1-arm polymer. These results suggest that amylose-based star polymers are a promising nanoplatform for glycobiomaterials.

収録刊行物

• BioMed Research International

  BioMed Research International 2015 2015

  Hindawi Publishing Corporation

詳細情報

• CRID: 1050564285785973120
• NII論文ID: 120005745655
• ISSN: 23146141
• HANDLE: 2433/210261
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles