Access this Article

Abstract

A new siRNA delivery system using a cationic glyco-star polymer is described. Spermine-modified 8-arm amylose star polymer (with a degree of polymerization of approximately 60 per arm) was synthesized by chemoenzymatic methods. The cationic star polymer effectively bound to siRNA and formed spherical complexes with an average hydrodynamic diameter of 230 nm. The cationic 8-arm star polymer complexes showed superior cellular uptake characteristics and higher gene silencing effects than a cationic 1-arm polymer. These results suggest that amylose-based star polymers are a promising nanoplatform for glycobiomaterials.

Journal

  • BioMed Research International

    BioMed Research International (2015), 2015

    Hindawi Publishing Corporation

Codes

  • NII Article ID (NAID)
    120005745655
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    2314-6141
  • Data Source
    IR 
Page Top