Non-periodic oscillatory deformation of an actomyosin microdroplet encapsulated within a lipid interface

• Nishigami, Yukinori

• Ito, Hiroaki

• Sonobe, Seiji

• Ichikawa, Masatoshi

Abstract

Active force generation in living organisms, which is mainly involved in actin cytoskeleton and myosin molecular motors, plays a crucial role in various biological processes. Although the contractile properties of actomyosin have been extensively investigated, their dynamic contribution to a deformable membrane remains unclear because of the cellular complexities and the difficulties associated with in vitro reconstitution. Here, by overcoming these experimental difficulties, we demonstrate the dynamic deformation of a reconstituted lipid interface coupled with self-organized structure of contractile actomyosin. Therein, the lipid interface repeatedly oscillates without any remarkable periods. The oscillatory deformation of the interface is caused by the aster-like three-dimensional hierarchical structure of actomyosin inside the droplet, which is revealed that the oscillation occurs stochastically as a Poisson process.

Journal

• Scientific Reports

  Scientific Reports 6 18964-, 2016-01-12

  Nature Publishing Group

Keywords

• Multidisciplinary

Details

• CRID: 1050282810809513088
• NII Article ID: 120005758237
• ISSN: 20452322
• DOI: 10.1038/srep18964
• HANDLE: 2433/212498
• Web Site: https://www.nature.com/articles/srep18964
• Web Site: https://www.nature.com/articles/srep18964.pdf
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN