Abstract
Article
Application of 1-oleoyl-2-acetyl-sn-glycerol (OAG), an analogue of diacylglycerol (DAG) formed via M_3 muscarinic receptors, induced inward cationic currents via a protein kinase C-independent mechanism and produced membrane depolarization with increased action potential discharges in mouse intestinal myocytes. Outside-out patches from the myocytes responded to OAG with openings of 115-pS channels characterized by a mean open time (O_τ) of 0.15 ms. M3 receptor stimulation is reportedly capable of causing brief openings (O_τ = 0.23 ms) of 120-pS cationic channels in intestinal myocytes, thus the present results strongly support the idea that the M_3-mediated 120-pS channel opening is brought about via DAG-dependent mechanisms.
Journal
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- European journal of pharmacology
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European journal of pharmacology 599 (1-3), 54-57, 2008-11
Elsevier
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Details 詳細情報について
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- CRID
- 1050001337488763136
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- NII Article ID
- 120005761342
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- ISSN
- 00142999
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- HANDLE
- 10659/1821
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- CiNii Articles