Targeting the canonical Wnt/β-catenin pathway in hematological malignancies
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抄録
The canonical Wnt/β-catenin pathway plays an important role in different developmental processes through the regulation of stem cell functions. In the activation of the canonical Wnt/β-catenin pathway, β-catenin protein is imported into the nucleus and activates transcription of target genes including cyclin D1 and c-myc. Aberrant activation of the Wnt/β-catenin pathway contributes to carcinogenesis and malignant behaviors, and Wnt signaling is essential for the maintenance of cancer stem cells. The canonical Wnt/β-catenin pathway has been investigated extensively as a target in cancer treatment and several specific inhibitors of this signaling pathway have been identified through high-throughput screening. In this review, the significance of the canonical Wnt/β-catenin pathway in hematological carcinogenesis and screening methods for specific inhibitors are discussed.
収録刊行物
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- Cancer science
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Cancer science 106 (6), 665-671, 2015-06
Wiley Publishing Asia Pty Ltd.
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詳細情報 詳細情報について
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- CRID
- 1050282810812299392
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- NII論文ID
- 120005767015
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- NII書誌ID
- AA11808050
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- ISSN
- 13479032
- 13497006
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- HANDLE
- 2433/215156
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles