Increased Serum KL-6 Levels Induced by Pulmonary Mycobacterium Avium Complex Infection in a Patient with RA-associated Lung Disease

• Waseda Koichi

• Ocho Kazuki

• Hasegawa Kou

• Kimura Kosuke

• Iwamuro Masaya

• Hanayama Yoshihisa

• Kondo Eisei

• Miyahara Nobuaki

• Otsuka Fumio

抄録

KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection.

収録刊行物

• Acta Medica Okayama

  Acta Medica Okayama 70 (3), 217-221, 2016-06

  Okayama University Medical School

キーワード

• KL-6
• mycobacterium avium complex
• pulmonary nontuberculous mycobacterium infection
• rheumatoid arthritis-associated interstitial lung disease
• bronchial alveolar lavage

詳細情報

• CRID: 1390290699796048512
• NII論文ID: 120005770691
• NII書誌ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/54422
• PubMed: 27339212
• Web Site: https://ousar.lib.okayama-u.ac.jp/54422
• Web Site: https://search.jamas.or.jp/link/ui/2017055398
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • PubMed
  • CiNii Articles