基本転写因子をｺｰﾄﾞする TAF7 ｲﾝﾄﾛﾝﾚｽ遺伝子の日本人男性における遺伝子多型解析

• TANAKA, Hiromitsu

• YOSHIMOTO, Tatsuaki

• NAKAMURA, Nobuhiro

• TAKEDA, Tsutomu

• WADA, Morimasa

• MIYAGAWA, Yasushi

• TSUJIMURA, Akira

• 田中, 宏光

• 吉本, 辰暁

• 中村, 信博

• 武田, 司

• 和田, 守正

• 宮川, 康

• 辻村, 晃

書誌事項

タイトル別名

• SNPs within the Intron-less TAF7 Gene Encoding a General Transcription Factor in Japanese Males

抄録

TAF7 is a part of the protein complex that is indispensable for the start of transcription. In the testis, TAF7 localizes on nuclei in spermatogonia and primary spermatocytes during proliferation. To examine whether genetic polymorphisms of the intron-less TAF7 gene are associated with male infertility, we screened TAF7 for genetic polymorphisms using DNA from 282 sterile and 96 fertile male volunteers. We identified 11 genetic polymorphisms in the TAF7 region. Although many single nucleotide polymorphisms (SNPs) have been reported in the SNP database of the National Center for Biotechnology Information, we found a novel CTC deletion and one SNP with an amino acid substitution in the TAF7 genomic region in infertile patients. These genetic polymorphisms might be causes of male sterility. These results will be useful for analyzing the association of traits and genetic polymorphisms in further large-scale genetic analyses.

収録刊行物

• 長崎国際大学論叢

  長崎国際大学論叢 16 197-201, 2016-03

  長崎国際大学

キーワード

• 不妊症
• 精巣
• 生殖細胞
• 精子形成
• 精原細胞
• RNAポリメラーゼ
• Infertility
• Testis
• Germ Cell
• Spermatogenesis
• Spermatogonia
• RNA polymerase

詳細情報

• CRID: 1050282813198314752
• NII論文ID: 120005772196
• NII書誌ID: AA11766493
• ISSN: 13464094
• NDL書誌ID: 027345122
• Web Site: https://niu.repo.nii.ac.jp/records/946
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027345122
• 本文言語コード: en
• 資料種別: departmental bulletin paper
• データソース種別:
  • IRDB
  • NDL
  • CiNii Articles