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Abstract

DNA has recently emerged as a promising material for the construction of nanosized architectures. Chemically modified DNA has been suggested to be an important component of such architectural building blocks. We have designed and synthesized a novel H-shaped DNA oligonucleotide dimer that is cross-linked with a structurally rigid linker composed of phenylene and ethynylene groups. A rotatable DNA unit was constructed through the self-assembly of this H-shaped DNA component and two complementary DNA oligonucleotides. In addition to the rotatable unit, a locked DNA unit containing two H-shaped DNA components was also constructed. As an example of an extended locked structure, a hexagonal DNA origami dimer and oligomer were constructed by using H-shaped DNA as linkers.

Journal

  • Nucleic Acids Res

    Nucleic Acids Res 43(14), 6692-6700, 2015-06-30

    Oxford University Press (OUP)

Codes

  • NII Article ID (NAID)
    120005818257
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0305-1048
  • Data Source
    IR 
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