Linking two DNA duplexes with a rigid linker for DNA nanotechnology

• 杉山, 弘

• Iwamoto, Masahiro

• Morinaga, Hironobu

• Emura, Tomoko

• Hidaka, Kumi

• Endo, Masayuki

• Sugiyama, Hiroshi

抄録

DNA has recently emerged as a promising material for the construction of nanosized architectures. Chemically modified DNA has been suggested to be an important component of such architectural building blocks. We have designed and synthesized a novel H-shaped DNA oligonucleotide dimer that is cross-linked with a structurally rigid linker composed of phenylene and ethynylene groups. A rotatable DNA unit was constructed through the self-assembly of this H-shaped DNA component and two complementary DNA oligonucleotides. In addition to the rotatable unit, a locked DNA unit containing two H-shaped DNA components was also constructed. As an example of an extended locked structure, a hexagonal DNA origami dimer and oligomer were constructed by using H-shaped DNA as linkers.

収録刊行物

• Nucleic Acids Res

  Nucleic Acids Res 43 (14), 6692-6700, 2015-06-30

  Oxford University Press (OUP)

詳細情報

• CRID: 1050564285789082240
• NII論文ID: 120005818257
• ISSN: 03051048
• HANDLE: 2433/215984
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles