CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells

• Kubo, Kaori

• Iwakami, Masashi

• Muromoto, Ryuta

• Inagaki, Takuya

• Kitai, Yuichi

• Kon, Shigeyuki

• Sekine, Yuichi

• Oritani, Kenji

• Matsuda, Tadashi

Abstract

Chronic myeloid leukemia is a clonal disease characterized by the presence of the Philadelphia chromosome and its oncogenic product, BCR-ABL, which activates multiple pathways involved in cell survival, growth promotion, and disease progression. We previously reported that in murine hematopoietic Ba/F3 cells, signal transducing adaptor protein-2 (STAP-2) binds to BCR-ABL and up-regulates BCR-ABL phosphorylation, leading to enhanced activation of its downstream signaling molecules. The binding of STAP2 to BCR-ABL also influenced the expression levels of chemokine receptors, such as CXCR4 and CCR7. For the induction of CCR7 expression, signals mediated by the MAPK/ERK pathway were critical in Ba/F3 cells expressing BCR-ABL and STAP-2. In addition, STAP-2 cooperated with BCR-ABL to induce the production of CCR7 ligands, CCL19 and CCL21. Our results demonstrate a contribution of CCR7 to STAP-2-dependent enhancement of BCR-ABL-mediated cell growth in Ba/F3 cells. (C) 2015 Elsevier Inc. All rights reserved.

Journal

• Biochemical and biophysical research communications

  Biochemical and biophysical research communications 463 (4), 825-831, 2015-08-07

  Elsevier

Keywords

• CML
• BCR-ABL
• STAP-2
• CCR7
• MAPK/ERK

Details

• CRID: 1050845763949351936
• NII Article ID: 120005822514
• HANDLE: 2115/62630
• ISSN: 0006291X
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles