Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

• Shiraishi Kouya

• Okada Yukinori

• Takahashi Atsushi

• Kamatani Yoichiro

• Momozawa Yukihide

• Ashikawa Kyota

• Kunitoh Hideo

• Matsumoto Shingo

• Takano Atsushi

• Shimizu Kimihiro

• Goto Akiteru

• Tsuta Koji

• Watanabe Shun-ichi

• Ohe Yuichiro

• Watanabe Yukio

• Goto Yasushi

• Nokihara Hiroshi

• Furuta Koh

• Yoshida Akihiko

• Goto Koichi

• Hishida Tomoyuki

• Tsuboi Masahiro

• Tsuchihara Katsuya

• Miyagi Yohei

• Tanaka Kazumi

• Nakayama Haruhiko

• Yokose Tomoyuki

• Nagashima Toshiteru

• Ohtaki Yoichi

• Maeda Daichi

• Imai Kazuhiro

• Minamiya Yoshihiro

• Sakamoto Hiromi

• Saito Akira

• Shimada Yoko

• Sunami Kuniko

• Saito Motonobu

• Inazawa Johji

• Nakamura Yusuke

• Yoshida Teruhiko

• Yokota Jun

• Matsuda Fumihiko

• Matsuo Keitaro

• Daigo Yataro

• Kubo Michiaki

• Kohno Takashi

• 前田 大地

抄録

金沢大学医薬保健研究域医学系

Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than in European/Americans (10-20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated with overall lung adenocarcinoma risk in East Asians, were re-discovered as loci associated with a higher susceptibility to EGFR mutation-positive lung adenocarcinoma. In addition, two additional loci, HLA class II at 6p21.32 (rs2179920; P =5.1 × 10 '17, per-allele OR=1.36) and 6p21.1 (FOXP4) (rs2495239; P=3.9 × 10 '9, per-allele OR=1.19) were newly identified as loci associated with EGFR mutation-positive lung adenocarcinoma. This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations.

収録刊行物

• Nature Research

  Nature Research 7 12451-, 2016-08-09

  Nature Publishing Group

詳細情報

• CRID: 1390009225523068160
• NII論文ID: 120005829411
• NII論文ID: 120006346597
• NII書誌ID: AA12645905
• ISSN: 20411723
• DOI: 10.24517/00062694
• HANDLE: 10422/00012326
• HANDLE: 2433/216381
• Web Site: http://hdl.handle.net/2297/00062694
• Web Site: https://shiga-med.repo.nii.ac.jp/records/3174
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • CiNii Articles