Relationship between the myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy

• Oda, Seiko

• Kobayashi, Shigeki

• Nanno, Takuma

• Ishiguchi, Hironori

• Myoren, Takeki

  Yamaguchi University

• Murakami, Wakako

• Mochizuki, Mamoru

• Oda, Tetsuro

• Okuda, Shinichi

• Yamada, Jutaro

• Okamura, Takayuki

• Matsuzaki, Masanori

  Yamaguchi University

• Yano, Masafumi

Abstract

We investigated the relationship between myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy (TC) compared with acute anteroseptal myocardial infarction (AMI). Methods: In 10 TC patients and 10 AMI patients, electrocardiogram, echocardiography, cardiac catheterization were conducted, and plasma catecholamines and urinary (U) 8-hydroxy-2’-deoxyguanosine (8-OHdG) as a marker of oxidative DNA damage were taken for one week from onset. Results: On admission, the coronary sinus (CS) had significantly higher norepinephrine (NE) and 8-OHdG levels than the aortic root (Ao) and peripheral blood vessels. Circulating catecholamines in TC patients tended to be higher than those in AMI patients

Journal

• The bulletin of the Yamaguchi Medical School

  The bulletin of the Yamaguchi Medical School 63 (1-2), 5-16, 2016

  Yamaguchi University School of Medicine

Keywords

• takotsubo cardiomyopathy
• oxidative stress
• catecholamine

Details

• CRID: 1050282812435906304
• NII Article ID: 120005842748
• NII Book ID: AA00594272
• ISSN: 05131812
• Web Site: https://petit.lib.yamaguchi-u.ac.jp/26486
• Web Site: https://search.jamas.or.jp/link/ui/2017191980
• Article Type: departmental bulletin paper
• Data Source:
  • IRDB
  • CiNii Articles