Formation of the circle of Willis during human embryonic development

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Author(s)

    • Takakuwa Tetsuya
    • Human Health Science, Graduate School of Medicine; Kyoto University; Kyoto Japan
    • Koike Teppei
    • Human Health Science, Graduate School of Medicine; Kyoto University; Kyoto Japan
    • Muranaka Taiga
    • Human Health Science, Graduate School of Medicine; Kyoto University; Kyoto Japan
    • Uwabe Chigako
    • Congenital Anomaly Research Center, Graduate School of Medicine; Kyoto University; Kyoto Japan
    • Yamada Shigehito
    • Congenital Anomaly Research Center, Graduate School of Medicine; Kyoto University; Kyoto Japan

Abstract

The circle of Willis (CW) is a circulatory anastomosis that supplies blood to the brain and adjacent structures. We examined the timing of formation of CW in 20 Japanese human embryo samples by using 3-dimensional reconstruction of serial histological sections. The CW was closed in 1 (n = 6), 2 (n = 8), 2 (n = 3) and 2 (n = 3) samples at Carnegie stages 20, 21, 22, and 23, respectively. The CW was unclosed in 13 samples (unclosed at ACOM alone, 6 samples; ACOM and bilateral P1, 4; left PCOM and right P1, 1; right PCOM and right P1, 1; ACOM and left PCOM, 1). It was difficult to predict whether the circle would close during further development, as such variations frequently exist in adults.

Journal

  • Congenital Anomalies

    Congenital Anomalies 56(5), 233-236, 2016-09-01

    Wiley-Blackwell

Codes

  • NII Article ID (NAID)
    120005850220
  • NII NACSIS-CAT ID (NCID)
    AN10066760
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0914-3505
  • Data Source
    IR  Crossref 
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