Gonadal soma-derived factor (gsdf), a TGF-beta superfamily gene, induces testis differentiation in the teleost fish Oreochromis niloticus

• Kaneko, Hiroyo

• Ijiri, Shigeho

• Kobayashi, Tohru

• Izumi, Hikari

• Kuramochi, Yuki

• Wang, De-Shou

• Mizuno, Shouta

• Nagahama, Yoshitaka

抄録

The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for differentiation of gonads into ovaries or testes using microarray screening. We focused on one of the isolated 12 candidate genes, #9475, which was an ortholog of gsdf (gonadal soma-derived factor), a member of the transforming growth factor-beta superfamily. #9475/gsdf showed sexual dimorphism in expression in XY gonads before any other testis differentiation-related genes identified in this species thus far. We also overexpressed the #9475/gsdf gene in)0( tilapia, and XX tilapia bearing the #9475/gsdf gene showed normal testis development, which suggests that #9475/gsdf plays an important role in male determination and/or differentiation in tilapia. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

収録刊行物

• Molecular and cellular endocrinology

  Molecular and cellular endocrinology 415 (C), 87-99, 2015-11-06

  Elsevier

キーワード

• gsdf
• Sex differentiation
• Sex determination
• dmrt1
• Nile tilapia

詳細情報

• CRID: 1050845763949424768
• NII論文ID: 120005855943
• NII書誌ID: AA00745811
• HANDLE: 2115/63427
• ISSN: 03037207
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles