Total Synthesis of (−)-Cardiopetaline

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Abstract

The total synthesis of (−)-cardiopetaline, an aconitine-type natural product, has been accomplished. Our synthesis involved a Wagner–Meerwein rearrangement of a sulfonyloxirane that enabled, in a single step, the construction of the bicyclo[3.2.1] system in the aconitine skeleton and effective introduction of oxygen functional groups at the appropriate positions.

Journal

  • Organic Letters

    Organic Letters 18 (10), 2359-2362, 2016-05-20

    ACS Publications

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