Fatal cardiac small-vessel involvement in ANCA-associated vasculitis: an autopsy case report
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Abstract
An 80-year-old Japanese man, who had fever and generalized fatigue not improved by antibiotics, was admitted to our hospital. Laboratory data indicative of renal dysfunction and antineutrophil cytoplasmic antibody (ANCA) in the serum led to the consideration of ANCA-associated vasculitis as a differential diagnosis. However, before the diagnostic confirmation, he was found dead on the bed. Autopsy revealed necrotizing crescentic glomerulonephritis in the kidneys. In addition, necrotizing granulomatous vasculitis with infiltration of multinucleated giant cells and neutrophils but not eosinophils was present in multiple organs. The direct cause of death was presumed as cardiac arrest by lethal arrhythmia because vasculitic lesions were distributed widely in the cardiac walls, acute congestion was observed in the systemic organs, and other causes of death were ruled out. This report presents the unusual manifestation of cardiac small-vessel involvement in ANCA-associated vasculitis related to sudden death.
Journal
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- Cardiovascular Pathology
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Cardiovascular Pathology 24 (6), 408-410, 2015-11
Elsevier
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Details 詳細情報について
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- CRID
- 1050845763949356544
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- NII Article ID
- 120005905594
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- NII Book ID
- AA10993310
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- HANDLE
- 2115/63950
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- ISSN
- 10548807
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- CiNii Articles