Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI

• Kato, Fumi

• Kudo, Kohsuke

• Yamashita, Hiroko

• Wang, Jeff

• Hosoda, Mitsuchika

• Hatanaka, Kanako C.

• Mimura, Rie

• Oyama-Manabe, Noriko

• Shirato, Hiroki

Bibliographic Information

Other Title

• Comparison between borderline ovarian tumors and carcinomas using semi-automated histogram analysis of diffusion-weighted imaging: focusing on solid components

Abstract

Purpose: To compare the morphology and minimum apparent diffusion coefficient (ADC) values among breast cancer subtypes. Methods: Ninety-three patients, who underwent breast MRI and collectively had 98 pathologically proven invasive carcinomas, were enrolled. Morphology was evaluated according to BIRADS-MRI. Minimum ADC was measured. Morphology and minimum ADC were compared among subtypes. Multivariate logistic regression analyses were used to identify the characteristics associated with different subtypes. Results: Oval/round shape was significantly associated with triple-negative (TN) cancer (TN vs. non-TN: 90.9% vs. 45.2%; p = 0.0123). Rim enhancement was significantly less frequent in Luminal A (Luminal A vs. non-Luminal A: 34.2% vs. 76.1%; p = 0.0003). The minimum ADC of Luminal A was significantly higher than that of Luminal B (HER2-negative) (834 vs. 748 x 10^-6 mm2/s; p <0.025). The minimum ADC of the TN-special type was significantly higher than that of TN-ductal (997 vs. 702 x 10^-6 mm2/s; p <0.025). On the multivariate analysis comparing the characteristics associated with Luminal A vs. Luminal B (HER2-negative), the internal enhancement characteristics of the mass and minimum ADC were significant factors. Conclusion: Morphology and minimum ADC would be useful in distinguishing breast cancer subtypes.

Journal

• European journal of radiology

  European journal of radiology 85 (1), 96-102, 2016-01

  Elsevier

Keywords

• Breast cancer subtypes
• Magnetic resonance imaging
• Diffusion weighed imaging
• Ki-67

Details

• CRID: 1050001202675095168
• NII Article ID: 120005905605
• NII Article ID: 50009768831
• DOI: 10.1007/s11604-016-0518-6
• ISSN: 1867108X
• ISSN: 0720048X
• ISSN: 18671071
• HANDLE: 2115/63971
• Web Site: http://link.springer.com/content/pdf/10.1007/s11604-016-0518-6.pdf
• Web Site: http://link.springer.com/article/10.1007/s11604-016-0518-6/fulltext.html
• Web Site: http://link.springer.com/content/pdf/10.1007/s11604-016-0518-6
• Web Site: https://search.jamas.or.jp/link/ui/2016263886
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN