Expression of Sorting Nexin 18 (SNX18) Is Dynamically Regulated in Developing Spinal Motor Neurons

• Nakazawa, Shiori

• Gotoh, Naoya

• Matsumoto, Hirotaka

• Murayama, Chiaki

• Suzuki, Toshiharu

• Yamamoto, Tohru

抄録

The sorting nexin (SNX) family proteins, which contain a Phox homology (PX) domain, play crucial roles in regulating the intracellular membrane trafficking of the endocytic pathway. The proper coordination of this pathway is important for axonal elongation; however, little is known about the expression and intracellular dynamics of the SNX members during the formation of the nervous system. Here we found that SNX18, which belongs to the Src-homology-3-PX-Bin/Amphiphysin/Rvs domain-containing SNX subfamily, was specifically expressed in differentiating motor neurons in the chick and mouse embryonic spinal cord. The expression of SNX18 in embryonic spinal motor neurons was transient and was down-regulated as the neurons matured. We further demonstrated that the localization of EGFP-SNX18 in growth cones was dynamically regulated and accumulated especially at areas in contact with permissive substrates. Our findings collectively suggest that SNX18 may play an active role in axonal elongation.

収録刊行物

• Journal of Histochemistry & Cytochemistry

  Journal of Histochemistry & Cytochemistry 59 (2), 202-213, 2011-02

  Sage Publications

キーワード

• sorting nexin
• SNX18
• SNX9-family
• motor neuron
• DRG neuron
• growth cone

詳細情報

• CRID: 1050001339009368320
• NII論文ID: 120005906550
• HANDLE: 2115/48172
• ISSN: 00221554
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles