AKT Plays a Crucial Role in Gastric Cancer.

機関リポジトリ Web Site

この論文をさがす

抄録

type:Article

The AKT protein is involved in the phosphatidylinositol-3 kinase signaling pathway and is a vital regulator of survival. proliferation, and differentiation of various types of cells. Helicobacter pylori induce epithelial cell proliferation and oxidative stress in chronic gastritis. These alterations lead to telomere shortening and resultant telomerase activation. Specifically, AKT is activated by H. pylori-induced inflammation; it subsequently promotes expression of human telomerase reverse transcriptase, which encodes a catalytic subunit of telomerase; and induces telomerase activity, which is an essential process of carcinogenesis. AKT activation is increased in gastric mucosa with carcinogenic properties and is associated with low survival of patients with gastric cancer. These findings suggest that AKT is pivotal in gastric carcinogenesis and progression.

identifier:Journal of Nara Medical Association Vol.67 No.1,2,3 p.1-9 (2016.06)

identifier:13450069

identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3297

identifier:Journal of Nara Medical Association, 67(1,2,3): 1-9

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ