Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide

• Dogishi, Koji

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Kodera, Mizuki

  Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital

• Oyama, Shohei

• Shirakawa, Hisashi

• Nakagawa, Takayuki

• Kaneko, Shuji

Abstract

We previously established a long-lasting cystitis model by an intravesical injection of hydrogen peroxide (H2O2) into mice. In this study, we assessed the pain-related behaviors in the cystitis model. An intravesical injection of 1.5% H2O2 transiently decreased spontaneous locomotor activity at 3 h after injection, indicative of acute spontaneous pain. In contrast, licking response to a bladder distention was slowly observed as licks to the lower abdomen at 7 and 14 days after injection, which was attenuated by amitriptyline and morphine, but not by oxybutynin. These results suggest that H2O2-induced chronic cystitis model shows delayed and long-lasting painful pathological condition.

Journal

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 129 244-246, 2015-12-01

  Elsevier BV

Keywords

• Chronic cystitis
• Hydrogen peroxide
• Painful bladder syndrome

Details

• CRID: 1050001335841093376
• NII Article ID: 120005980861
• NII Book ID: AA11806667
• ISSN: 13478648
• ISSN: 13478613
• HANDLE: 2433/218469
• Web Site: https://search.jamas.or.jp/link/ui/2016276056
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles