A Divergent Approach to the Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from Atropisomeric N-Aryl Oxindole Derivatives

• Nakazaki, Atsuo

• Mori, Ayako

• Kobayashi, Susumu

• Nishikawa, Toshio

抄録

3,3-Disubstituted oxindoles were divergently synthesized by diastereoselective transformations including nucleophilic addition, alkylation, and cycloaddition using common, axially chiral N-aryl oxindoles. Notably, high diastereoselectivities (up to >95:5) were observed with ortho-monosubstituted N-aryl oxindoles to give various oxindole scaffolds, and facile removal of the p-(benzyloxy)aryl moiety in axially twisted amides was achieved by a mild, two-step sequence.

収録刊行物

• Chemistry-An Asian Journal

  Chemistry-An Asian Journal 11 (22), 3267-3274, 2016-11-22

  Wiley

詳細情報

• CRID: 1050564288759126400
• NII論文ID: 120005981190
• HANDLE: 2237/25699
• ISSN: 18614728
• Web Site: https://nagoya.repo.nii.ac.jp/records/23506
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles