Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1

• Togi, Sumihito

• Hatano, Yosuke

• Muromoto, Ryuta

• Kawanishi, Eri

• Ikeda, Osamu

• Hirashima, Koki

• Kon, Shigeyuki

• Kitai, Yuichi

• Yasui, Teruhito

• Oritani, Kenji

• Matsuda, Tadashi

抄録

Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) plays pathogenic roles in EBV-related diseases. Thus, host cells employ several mechanisms to regulate LMP1 functions, and we previously reported possible regulation by signal transducing adaptor protein-2 as well as BS69. Here, we found that caspase-3 mainly degraded LMP1 proteins in HeLa cells, leading to decreased NF-kappa B and STAT3 activation. Caspase-3 cleaved the consensus DNTD sequences in the CTAR3 region of LMP1. Of importance, LMP1 expression strongly enhanced caspase-3 activity. Taken together, the reduction of LMP1 protein levels by caspases is likely to be a newly identified host defense against EBV infection.

収録刊行物

• FEBS Letters

  FEBS Letters 590 (6), 808-818, 2016-03

  Wiley-Blackwell

キーワード

• caspase
• degradation
• EBV
• LMP1
• NF-kappa B activation

詳細情報

• CRID: 1050282813997157248
• NII論文ID: 120005981517
• HANDLE: 2115/64895
• ISSN: 00145793
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles