Effects of Fetal Exposure to Asian Sand Dust on Development and Reproduction in Male Offspring

• 高野, 裕久

• Ichinose, Takamichi

• Arashidani, Keiichi

• He, Miao

• Takano, Hirohisa

• Shibamoto, Takayuki

抄録

In recent experimental studies, we reported the aggravating effects of Asian sand dust (ASD) on male reproduction in mice. However, the effects of fetal ASD exposure on male reproduction have not been investigated. The present study investigated the effects of fetal ASD exposure on reproduction in male offspring. Using pregnant CD-1 mice, ASD was administered intratracheally on days 7 and 14 of gestation, and the reproduction of male offspring was determined at 5, 10, and 15 weeks after birth. The secondary sex ratio was significantly lower in the fetal ASD-exposed mice than in the controls. Histologic examination showed partial vacuolation of seminiferous tubules in immature mice. Moreover, daily sperm production (DSP) was significantly less in the fetal ASD-exposed mice than in the controls. DSP in the fetal ASD-exposed mice was approximately 10% less than the controls at both 5 and 10 weeks. However, both the histologic changes and the DSP decrease were reversed as the mice matured. These findings suggest that ASD exposure affects both the fetal development and the reproduction of male offspring. In the future, it will be necessary to clarify the onset mechanisms of ASD-induced male fetus death and male reproductive disorders.

収録刊行物

• International Journal of Environmental Research and Public Health

  International Journal of Environmental Research and Public Health 13 (11), 2016-11-23

  MDPI AG

キーワード

• Asian sand dust
• in utero exposure
• secondary sex ratio
• male reproduction
• daily sperm production

詳細情報

• CRID: 1050564285794564480
• NII論文ID: 120005997696
• ISSN: 16604601
• ISSN: 16617827
• HANDLE: 2433/218627
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles