Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival

• 柿澤, 昌

• Kakizawa, Sho

• Yamazawa, Toshiko

抄録

Although precise cellular and molecular mechanisms underlying neurodegeneration still remain enigmatic, key factors associated with degenerative disorders, such as glutamate toxicity and oxidative stress, have been recently identified. Accordingly, there has been growing interest in examining the effects of exogenous and endogenous molecules on neuroprotection and neurodegeneration. In this paper, we review recent studies on neuroprotective and/or neurodegenerative effects of natural products, such as caffeic acid and chlorogenic acid, and gaseous mediators, including hydrogen sulfide and nitric oxide. Furthermore, possible molecular mechanisms of these molecules in relation to glutamate signals are discussed. Insight into the pathophysiological role of these molecules will make progress in our understanding of molecular mechanisms underlying neurodegenerative diseases, and is expected to lead to potential therapeutic approaches.

収録刊行物

• International Journal of Molecular Sciences

  International Journal of Molecular Sciences 17 (10), 2016-09-29

  MDPI AG

キーワード

• chlorogenic acid
• glutamate neurotoxicity
• hydrogen sulfide
• neuroprotection
• nitric oxide

詳細情報

• CRID: 1050845760771275136
• NII論文ID: 120005997697
• ISSN: 14220067
• HANDLE: 2433/218628
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles