Formal Total Synthesis of Manzacidin C Based on Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Imines

• Tong, Thu Minh Thi

• Soeta, Takahiro

• Suga, Takuya

• Kawamoto, Keisuke

• Hayashi, Yoshihito

• Ukaji, Yutaka

• 添田, 貴宏

• 菅, 拓也

• 川本, 圭祐

• 林, 宜仁

• 宇梶, 裕

Abstract

An enantioselective formal total synthesis of (+)-manzacidin C is described. A key feature of the synthesis is the construction of two chiral centers via the asymmetric 1,3-dipolar cycloaddition of an azomethine imine to methallyl alcohol by the use of (S,S)-DIPT as a chiral auxiliary. © 2017 American Chemical Society.

Embargo Period 12 months

Journal

• Journal of Organic Chemistry

  Journal of Organic Chemistry 82 (4), 1969-1976, 2017-02-17

  American Chemical Society

Details

• CRID: 1050564285895888896
• NII Article ID: 120006027761
• NII Book ID: AA00704100
• ISSN: 00223263
• Web Site: http://hdl.handle.net/2297/46979
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles