Time‐ and dose‐dependent effects of total‐body ionizing radiation on muscle stem cells

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Exposure to high levels of genotoxic stress, such as high-dose ionizing radiation, increases both cancer and noncancer risks. However, it remains debatable whether low-dose ionizing radiation reduces cellular function, or rather induces hormetic health benefits. Here, we investigated the effects of totalbody c-ray radiation on muscle stem cells, called satellite cells. Adult C57BL/6 mice were exposed to c-radiation at low- to high-dose rates (low, 2 or 10 mGy/day; moderate, 50 mGy/day; high, 250 mGy/day) for 30 days. No hormetic responses in proliferation, differentiation, or self-renewal of satellite cells were observed in low-dose radiation-exposed mice at the acute phase. However, at the chronic phase, population expansion of satellite cell-derived progeny was slightly decreased in mice exposed to low-dose radiation. Taken together, low-dose ionizing irradiation may suppress satellite cell function, rather than induce hormetic health benefits, in skeletal muscle in adult mice.


  • Physiological Reports

    Physiological Reports 3(4), e12377, 2015-04-13

    American Physiological Society and The Physiological Society


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