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Abstract

A mild and sustainable synthesis of 2, 2-disubstituted oxetanes has been achieved through the use of a flow microreactor system. By controlling the residence time a highly unstable intermediate such as 2-phenyloxetan-2-yl lithium can be generated and trapped with various electrophiles affording in moderate to good yields 2-substituted-2-phenyloxetanes at higher temperatures with respect to macrobatch-mode where –78 °C is required.

Journal

  • Open Chemistry

    Open Chemistry 14(1), 377-382, 2016-01

    Walter de Gruyter GmbH

Codes

  • NII Article ID (NAID)
    120006305900
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    2391-5420
  • Data Source
    IR 
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