Biological and physicochemical functions of ubiquitylation revealed by synthetic chemistry approaches

• 森本, 大智

• 菅瀬, 謙治

• Sugase, Kenji

• Shirakawa, Masahiro

抄録

Most intracellular proteins are subjected to post-translational modification by ubiquitin. Accordingly, it is of fundamental importance to investigate the biological and physicochemical effects of ubiquitylation on substrate proteins. However, preparation of ubiquitylated proteins by an enzymatic synthesis bears limitations in terms of yield and site-specificity. Recently established chemical ubiquitylation methodologies can overcome these problems and provide a new understanding of ubiquitylation. Herein we describe the recent chemical ubiquitylation procedures with a focus on the effects of ubiquitylation on target proteins revealed by the synthetic approach.

収録刊行物

• International Journal of Molecular Sciences

  International Journal of Molecular Sciences 18 (6), 1145-, 2017-05-27

  MDPI AG

キーワード

• ubiquitin
• post-translational modification
• chemical ubiquitylation
• site-directed conjugation

詳細情報

• CRID: 1050001335849279360
• NII論文ID: 120006318888
• ISSN: 16616596
• ISSN: 16604601
• ISSN: 14220067
• ISSN: 16617827
• DOI: 10.3390/ijms18061145
• HANDLE: 2433/226315
• Web Site: http://www.mdpi.com/1422-0067/18/6/1145/pdf
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN