Foxp2 Regulates Identities and Projection Patterns of Thalamic Nuclei during Development

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Abstract

The molecular mechanisms underlying the formation of the thalamus during development have been investigated intensively. Although transcription factors distinguishing the thalamic primordium from adjacent brain structures have been uncovered, those involved in patterning inside the thalamus are largely unclear. Here, we show that Foxp2, a member of the forkhead transcription factor family, regulates thalamic patterning during development. We found a graded expression pattern of Foxp2 in the thalamic primordium of the mouse embryo. The expression levels of Foxp2 were high in the posterior region and low in the anterior region of the thalamic primordium. In Foxp2 (R552H) knockin mice, which have a missense loss-of-function mutation in the forkhead domain of Foxp2, thalamic nuclei of the posterior region of the thalamus were shrunken, while those of the intermediate region were expanded. Consistently, Foxp2 (R552H) knockin mice showed changes in thalamocortical projection patterns. Our results uncovered important roles of Foxp2 in thalamic patterning and thalamocortical projections during development. © 2017 Author.

Embargo Period 12 months

Journal

  • Cerebral Cortex

    Cerebral Cortex 27(7), 3648-3659, 2017-07-01

    Oxford University Press

Codes

  • NII Article ID (NAID)
    120006334915
  • NII NACSIS-CAT ID (NCID)
    AA10777916
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1047-3211
  • Data Source
    IR 
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