第20回徳島医学会賞受賞論文 高リン血症と心血管疾患  [in Japanese] Hyperphosphatemia and cardiovascular disease  [in Japanese]

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Abstract

Hyperphosphatemia has been known as a risk factor for cardiovascular disease particularly inchronic kidney disease patients. Hyperphosphatemia can be involved in the calcification of vascularsmooth muscle cells, resulting in M¨onkeberg medial calcific sclerosis which is a type of arteriosclerosis.However, it has not been clarified whether hyperphosphatemia can deteriorate endothelialfunction and can be a risk factor of atherosclerosis. Our recent study demonstrated that hyperphosphatemiaincreased oxidative stress and decreased nitric oxide production in endothelial cells.In addition, hyperphosphatemia attenuated endothelium-dependent vasodilation reaction. Theseobservations suggest that hyperphosphatemia may cause endothelial dysfunction, and be an importantfactor for progression of atherosclerosis as well as vascular calcification. Positive associationbetween hyperphosphatemia and cardiovascular disease may be explained by the dual harmfuleffects of phosphorus on the vessels.

Journal

  • Shikoku acta medica

    Shikoku acta medica 64(3・4), 114-116, 2008-08-25

    徳島医学会

Codes

  • NII Article ID (NAID)
    120006335075
  • NII NACSIS-CAT ID (NCID)
    AN00102041
  • Text Lang
    JPN
  • Article Type
    journal article
  • Journal Type
    大学紀要
  • ISSN
    00373699
  • NDL Article ID
    9693650
  • NDL Source Classification
    ZS7(科学技術--医学)
  • NDL Call No.
    Z19-344
  • Data Source
    NDL  IR 
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