Boron Neutron Capture Therapy for Malignant Brain Tumors

• MIYATAKE Shin-Ichi

  Cancer Center, Osaka Medical College Department of Neurosurgery, Osaka Medical College

• KAWABATA Shinji

  Department of Neurosurgery, Osaka Medical College

• HIRAMATSU Ryo

  Department of Neurosurgery, Osaka Medical College

• KUROIWA Toshihiko

  Department of Neurosurgery, Osaka Medical College

• SUZUKI Minoru

  Particle Radiation Oncology Research Center, Kyoto University Research, Reactor Institute

• KONDO Natsuko

  Particle Radiation Oncology Research Center, Kyoto University Research, Reactor Institute

• ONO Koji

  Particle Radiation Oncology Research Center, Kyoto University Research, Reactor Institute

抄録

Boron neutron capture therapy (BNCT) is a biochemically targeted radiotherapy based on the nuclear capture and fission reactions that occur when non-radioactive boron-10, which is a constituent of natural elemental boron, is irradiated with low energy thermal neutrons to yield high linear energy transfer alpha particles and recoiling lithium-7 nuclei. Therefore, BNCT enables the application of a high dose of particle radiation selectively to tumor cells in which boron-10 compound has been accumulated. We applied BNCT using nuclear reactors for 167 cases of malignant brain tumors, including recurrent malignant gliomas, newly diagnosed malignant gliomas, and recurrent high-grade meningiomas from January 2002 to May 2014. Here, we review the principle and history of BNCT. In addition, we introduce fluoride-18-labeled boronophenylalanine positron emission tomography and the clinical results of BNCT for the above-mentioned malignant brain tumors. Finally, we discuss the recent development of accelerators producing epithermal neutron beams. This development could provide an alternative to the current use of specially modified nuclear reactors as a neutron source, and could allow BNCT to be performed in a hospital setting.

収録刊行物

• Neurologia medico-chirurgica

  Neurologia medico-chirurgica 56 (7), 361-371, 2016

  一般社団法人 日本脳神経外科学会

キーワード

• boron neutron capture therapy
• malignant glioma
• glioblastoma
• high-grade meningioma
• positron emission tomography

詳細情報

• CRID: 1390001205057143040
• NII論文ID: 130005165070
• NII論文ID: 120006335649
• DOI: 10.2176/nmc.ra.2015-0297
• ISSN: 13498029
• ISSN: 04708105
• HANDLE: 2433/226821
• PubMed: 27250576
• Web Site: https://www.jstage.jst.go.jp/article/nmc/56/7/56_ra.2015-0297/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017023473
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • Crossref
  • PubMed
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  • KAKEN
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