Prolonged neutropenia due to antihuman neutrophil antigen 2 (CD177) antibody after bone marrow transplantation

Access this Article

Search this Article

Abstract

We describe a patient who presented with prolonged neutropenia due to anti-human neutrophil antigen (HNA)-2 (CD177) antibody after allogeneic bone marrow transplantation. A granulocyte immunofluorescence test showed bimodal expression of antineutrophil antibody that resulted from specific binding of anti-HNA-2 to CD177+ neutrophils from healthy donors. The patient did not respond to granulocyte colony stimulating factor, which is able to upregulate CD177 expression on neutrophils. The low percentage of CD177+ cells in the few remaining neutrophils supports the possibility of elimination of CD177-upregulated neutrophils. These findings might explain an inferior response to neutrophil growth factors in neutropenia secondary to anti-HNA-2 antibody. © 2016 Wiley Periodicals, Inc.

Embargo Period 12 months

Journal

  • Pediatric Blood and Cancer

    Pediatric Blood and Cancer 64(7), e26388, 2017-07-01

    John Wiley and Sons Inc.

Codes

  • NII Article ID (NAID)
    120006338397
  • NII NACSIS-CAT ID (NCID)
    AA11876210
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1545-5009
  • Data Source
    IR 
Page Top