The role of lipid droplets in metabolic disease in rodents and humans

• Greenberg, Andrew S.

• Coleman, Rosalind A.

• Kraemer, Fredric B.

• McManaman, James L.

• Obin, Martin S.

• Puri, Vishwajeet

• Yan, Qing-Wu

• Miyoshi, Hideaki

• Mashek, Douglas G.

抄録

Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.

収録刊行物

• The Journal of clinical investigation

  The Journal of clinical investigation 121 (6), 2102-2110, 2011-06-01

  American Society for Clinical Investigation

詳細情報

• CRID: 1050845763954289280
• NII論文ID: 120006352220
• HANDLE: 2115/67266
• ISSN: 00219738
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles