Novel aspects of extracellular adenosine dynamics revealed by adenosine sensor cells

• Yamashiro, Kunihiko

• Morita, Mitsuhiro

Abstract

Adenosine modulates diverse physiological and pathological processes in the brain, including neuronal activities, blood flow, and inflammation. However, the mechanisms underlying the dynamics of extracellular adenosine are not fully understood. We have recently developed a novel biosensor, called an adenosine sensor cell, and we have characterized the neuronal and astrocytic pathways for elevating extracellular adenosine. In this review, the physiological implications and therapeutic potential of the pathways revealed by the adenosine sensor cells are discussed. We propose that the multiple pathways regulating extracellular adenosine allow for the diverse functions of this neuromodulator, and their malfunctions cause various neurological and psychiatric disorders.

Journal

• Neural Regeneration Research

  Neural Regeneration Research 12 (6), 881-885, 2017-06

  Medknow Publications

Keywords

• Developmental Neuroscience

Details

• CRID: 1050856995323825664
• NII Article ID: 120006358587
• DOI: 10.4103/1673-5374.208544
• ISSN: 18767958
• ISSN: 16735374
• HANDLE: 20.500.14094/90004269
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN