Chimpanzee Down syndrome: a case study of trisomy 22 in a captive chimpanzee

• Hirata, Satoshi

  Kumamoto Sanctuary, Wildlife Research Center, Kyoto University

• Hirai, Hirohisa

  Primate Research Institute, Kyoto University

• Nogami, Etsuko

  Kumamoto Sanctuary, Wildlife Research Center, Kyoto University

• Morimura, Naruki

  Kumamoto Sanctuary, Wildlife Research Center, Kyoto University

• Udono, Toshifumi

  Kumamoto Sanctuary, Wildlife Research Center, Kyoto University

Abstract

We report a case of chimpanzee trisomy 22 in a captive-born female. Because chromosome 22 in great apes is homologous to human chromosome 21, the present case is analogous to human trisomy 21, also called Down syndrome. The chimpanzee in the present case experienced retarded growth; infantile cataract and vision problems, including nystagmus, strabismus, and keratoconus; congenital atrial septal defect; and hypodontia. All of these symptoms are common in human Down syndrome. This case was the second reported case of trisomy 22 in the chimpanzee. The chimpanzee in our case became blind by 7 years old, making social life with other chimpanzees difficult, but opportunities to interact with other conspecific individuals have been offered routinely. We believe that providing her with the best care over the course of her life will be essential.

Journal

• Primates

  Primates 58 (2), 267-273, 2017-04

  Springer Nature

Keywords

• Chimpanzee
• Trisomy
• Chromosomal abnormality
• Down syndrome
• Cataract
• Atrial septal defect

Details

• CRID: 1050564285805414912
• NII Article ID: 120006370724
• NII Book ID: AA00355624
• ISSN: 00328332
• ISSN: 16107365
• DOI: 10.1007/s10329-017-0597-8
• HANDLE: 2433/228259
• Web Site: http://link.springer.com/content/pdf/10.1007/s10329-017-0597-8.pdf
• Web Site: http://link.springer.com/article/10.1007/s10329-017-0597-8/fulltext.html
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN