Passive immunotherapy of tauopathy targeting pSer413-tau : a pilot study in mice

• Umeda, Tomohiro

• Eguchi, Hiroshi

• Kunori, Yuichi

• Matsumoto, Yoichi

• Taniguchi, Taizo

• Mori, Hiroshi

• Tomiyama, Takami

Abstract

Objective: Cellular inclusions of hyperphosphorylated tau are a hallmark of tauopathies, which are neurodegenerative disorders that include Alzheimer's disease (AD). Active and passive immunization against hyperphosphorylated tau has been shown to attenuate phenotypes in model mice. We developed new monoclonal antibodies to hyperphosphorylated tau and sought high therapeutic efficacy for future clinical use. / Methods: Using more than 20 antibodies, we investigated which sites on tau are phosphorylated early and highly in the tauopathy mouse models tau609 and tau784. These mice display tau hyperphosphorylation, synapse loss, memory impairment at 6 months, and tangle formation and neuronal loss at 15 months. We generated mouse monoclonal antibodies to selected epitopes and examined their effects on memory and tau pathology in aged tau609 and tau784 mice by the Morris water maze and by histological and biochemical analyses....

Journal

• Annals of Clinical and Translational Neurology

  Annals of Clinical and Translational Neurology 2 (3), 241-255, 2015-03

  Wiley

Details

• CRID: 1050001202454664192
• NII Article ID: 120006371273
• ISSN: 23289503
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_23289503-2-3-241
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles