Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers

• Umeda, Tomohiro

• Ono, Kenjiro

• Sakai, Ayumi

• Yamashita, Minato

• Mizuguchi, Mineyuki

• Klein, William L.

• Yamada, Masahito

• Mori, Hiroshi

• Tomiyama, Takami

Abstract

Amyloid-β, tau, and α-synuclein, or more specifically their soluble oligomers, are the aetiologic molecules in Alzheimer's disease, tauopathies, and α-synucleinopathies, respectively. These proteins have been shown to interact to accelerate each other's pathology. Clinical studies of amyloid-β-targeting therapies in Alzheimer's disease have revealed that the treatments after disease onset have little benefit on patient cognition....

Journal

• Brain

  Brain 139 (5), 1568-1586, 2016-03-28

  Oxford University Press

Keywords

• 神経変性疾患
• neurodegenerative disease
• prevention
• oligomer
• mitochondria
• autophagy

Details

• CRID: 1050282677429064448
• NII Article ID: 120006371274
• ISSN: 00068950
• ISSN: 14602156
• DOI: 10.1093/brain/aww042
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_00068950-139-5-1568
• Web Site: http://academic.oup.com/brain/article-pdf/139/5/1568/17349396/aww042.pdf
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN