Synthesis of glycoconjugate polymer carrying globotriaose as artificial multivalent ligand for Shiga toxin-producing Escherichia coli O157 : H7

• 松岡, 浩司

• 照沼, 大陽

Abstract

type:text

As an artificial ligand, a glycoconjugate polymer carrying carbohydrate moiety of lactosyl ceramide or globotriaosyl ceramide (Gb3) was synthesized. Gb3 is known as the receptor of Shiga toxin-producing Escherichia coli O157: H7. The preparation of the glycoconjugate polymer initially involves the construction of the carbohydrate moiety of Gb3 derivative which has n-pentenyl group as polymerizable group. In addition, the n-pentenyl group of the Gb3 derivative was modified and different polymerizable groups such as acrylamide group were introduced at ω-position of the aglycon. Radical polymerization of the synthesized glycosyl monomers with or without acrylamide proceeded smoothly in water using ammonium persulfate and N, N, N′, N′-tetramethylethylenediamine as usual initiator system and gave water-soluble glycoconjugate polymers having various polymer compositions. These polymers have the potential to neutralize Shiga toxin by reason of cluster effect and multivalency.

identifier:http://www.sciencedirect.com/science/journal/01448617

Journal

• Carbohydrate polymers

  Carbohydrate polymers 57 (4), 441-450, 2004

  Elsevier Science Ltd.

Keywords

• Escherichia coli
• Shiga toxins
• Glycoconjugate polymer
• Radical polymerization
• Carbohydrates
• Globotriaose

Details

• CRID: 1050282812794504064
• NII Article ID: 120006384990
• ISSN: 01448617
• Web Site: http://id.nii.ac.jp/1586/00012498/
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles