A cyanobacterial gene encoding an ortholog of Pirin is induced under stress conditions

• 日原, 由香子

抄録

type:text

Pirin is a recently identified protein in eukaryotes as a transcription cofactor or as an apoptosis-related protein. Although Pirin is highly conserved from bacteria to human, there have been no reports on prokaryotic Pirin orthologs. We show here that pirA (sll1773) encoding an ortholog of Pirin and together with an adjacent gene, pirB (ssl3389), was up-regulated under high salinity and some other stress conditions in a cyanobacterium Synechocystis sp. PCC 6803. Induction of the pirAB genes was not related to cell death and disruption of pirA did not affect the gene expression profile. Expression of the pirAB genes was negatively regulated by a LysR family LysR family transcriptional regulator encoded by pirR (slr1871) located immediately upstream of pirAB in the divergent direction. DNA microarray analysis indicated that PirR repressed expression of closely located ORFs, slr1870 and mutS (sll1772), in addition to pirAB and pirR itself.

identifier:http://www.sciencedirect.com/science/journal/00145793

収録刊行物

• FEBS letters

  FEBS letters 574 (1-3), 101-105, 2004

  Elsevier

キーワード

• Pirin
• Salt stress
• Synechocystis sp. PCC 6803
• Transcriptional regulation
• LysR family
• DNA microarray

詳細情報

• CRID: 1050001337817796224
• NII論文ID: 120006385000
• ISSN: 00145793
• Web Site: http://id.nii.ac.jp/1586/00012508/
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles