Kaempulchraols IO: new isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity

• Win, Nwet Nwet

• Ito, Takuya

• Aimaiti, Simayijiang

• Kodama, Takeshi

• Imagawa, Hiroshi

• Ngwe, Hla

• Asakawa, Yoshinori

• Abe, Ikuro

• Morita, Hiroyuki

Abstract

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The isolation of the CHCl3 soluble extract of Kaempferia pulchra rhizomes afforded seven new isopimarane diterpenoids, kaempulchraols I−O, together with one known analogue. The structures of these compounds were elucidated using 1D and 2D NMR and X-ray diffraction analyses. The antiproliferative activity of the isolated compounds was evaluated against a panel of five human cancer cell lines. Kaempulchraol L exhibited weak antiproliferative activity against PANC-1 and PSN-1 cells with IC50 values of 39.9 and 22.6 μM, respectively.

Article

Tetrahedron, 2015 Jul; 71(29): 4707-13

Journal

• Tetrahedron

  Tetrahedron 71 (29), 4707-4713, 2015-07

  Elsevier Science

Keywords

• Kaempferia pulchra
• isopimarane diterpenoids
• kaempulchraols
• antiproliferative activity

Details

• CRID: 1050282814082631808
• NII Article ID: 120006389600
• NII Book ID: AA00861787
• ISSN: 00404020
• HANDLE: 10110/00018120
• Web Site: https://toyama.repo.nii.ac.jp/records/15656
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles