Kaempulchraols A−H, diterpenoids from the rhizomes of Kaempferia pulchra collected in Myanmar

• Win, Nwet Nwet

• Ito, Takuya

• Aimaiti, Simayijiang

• Imagawa, Hiroshi

• Ngwe, Hla

• Abe, Ikuro

• Morita, Hiroyuki

Abstract

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Eight new diterpenoids, kaempulchraols A−H (1−8), along with five known analogues were isolated from the CHCl3 soluble extract of rhizomes of Kaempferia pulchra of Myanmar. The structures of these compounds were elucidated using extensive spectroscopic techniques including X-ray diffraction analysis. All the isolates were tested for their antiproliferative activity against a panel of five human cancer cell lines (A549, human lung cancer; HeLa, human cervix cancer; PANC-1 and PSN-1, human pancreatic cancer, MDA-MB-231, human breast cancer) and TIG-3, normal human primary fibroblast cells. Kaempulchraol F (6) exhibited weak activity against human pancreatic PSN-1 cell line with an IC50 value of 12.3 μM.

Article

J Nat Prod, 2015 May; 78(5): 1113-8

Journal

• Jouranl of Natural Products

  Jouranl of Natural Products 78 (5), 1113-1118, 2015-05

  American Society of Pharmacognosy and the Lloyd Library and Museum

Details

• CRID: 1050564289059343360
• NII Article ID: 120006389601
• NII Book ID: AA00258639
• ISSN: 01633864
• ISSN: 15206025
• HANDLE: 10110/00018122
• Web Site: https://toyama.repo.nii.ac.jp/records/15657
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles