eCG/hCG処理した未成熟雌マウスの卵巣におけるPin1(ペプチジルプロピルイソメラーゼ)の発現

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  • SHIMIZU Takashi
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Graduate School of Agricultural Science, Tohoku University
  • AKIYAMA Hirotada
    Center for Interdisciplinary Research, Tohoku University
  • ABE Yasuyuki
    Graduate School of Agricultural Science, Tohoku University
  • SASADA Hiroshi
    Graduate School of Agricultural Science, Tohoku University
  • SATO Eimei
    Graduate School of Agricultural Science, Tohoku University
  • MIYAMOTO Akio
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine
  • UCHIDA Takafumi
    Center for Interdisciplinary Research, Tohoku University

書誌事項

タイトル別名
  • Expression of Pin1, a Peptidyl-Prolyl Isomerase, in the Ovaries of eCG/hCG-Treated Immature Female Mice

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Protein phosphorylation on certain serine or threonine residues preceding proline (Ser/Thr-Pro) is a pivotal signaling mechanism in diverse cellular processes. Pin1 is a highly conserved enzyme that isomerizes only the phosphorylated Ser/Thr-Pro bonds in certain proteins, thereby inducing conformational changes. Although much protein is phosphorylated in the ovary, the role of Pin1 in the ovary is still unknown. The purpose of this study is to investigate the effects of gonadotropins on protein and mRNA expression of Pin1 in mice ovaries. Quantitative PCR analysis showed that the expression of Pin1 mRNA significantly increased in the ovaries of equine chorionic gonadotropin (eCG)-treated mice compared with those of untreated mice (P<0.05). However, human chorionic gonadotropin (hCG) attenuated the expression of Pin1 mRNA increased by eCG. The protein level of Pin1 showed the same tendency as the expression of mRNA. The mRNA expression of E2F transcription factor, which controlled the expression of Pin1, was significantly decreased in the eCG-treated ovaries compared with the controls (P<0.05). These observations suggest that gonadotropins may regulate the expression of Pin1 without E2F transcription factor, indicating that Pin1 might be an important factor for protein signal transduction during follicular development.<br>

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