Mycophenolic acid and its derivatives as potential chemotherapeutic agents targeting inosine monophosphate dehydrogenase in Trypanosoma congolense

• 菅沼, 啓輔

• Sarwono, Albertus Eka Yudistira

• Mitsuhashi, Shinya

• Jąkalski, Marcin

• Okada, Tadashi

• Nthatisi, Molefe

• Yamagishi, Junya

• Ubukata, Makoto

• 井上, 昇

抄録

This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense. The proliferation of T. congolense was completely inhibited by adding <1 mu M MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularly characterized as the target of these compounds. The results suggest that MPA and its derivatives have the potential to be new candidates as novel trypanocidal drugs.

収録刊行物

• Antimicrobial Agents and Chemotherapy

  Antimicrobial Agents and Chemotherapy 60 (7), 4391-4393, 2016-07

  American Society for Microbiology

詳細情報

• CRID: 1050001337584032640
• NII論文ID: 120006390948
• NII書誌ID: AA00542574
• ISSN: 00664804
• Web Site: https://obihiro.repo.nii.ac.jp/records/1211
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles