Inorganic nanoparticles kill <em>Toxoplasma gondii</em> via changes in redox status and mitochondrial membrane potential

• Adeyemi, Oluyomi Stephen

• Murata, Yuho

• Sugi, Tatsuki

• 加藤, 健太郎

書誌事項

タイトル別名

• Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential

抄録

This study evaluated the anti-Toxoplasma gondii potential of gold, silver, and platinum nanoparticles (NPs). Inorganic NPs (0.01-1,000 mu g/mL) were screened for antiparasitic activity. The NPs caused >90% inhibition of T. gondii growth with EC50 values of <= 7, <= 1, and <= 100 mu g/mL for gold, silver, and platinum NPs, respectively. The NPs showed no host cell cytotoxicity at the effective anti-T. gondii concentrations; the estimated selectivity index revealed a >= 20-fold activity toward the parasite versus the host cell. The anti-T. gondii activity of the NPs, which may be linked to redox signaling, affected the parasite mitochondrial membrane potential and parasite invasion, replication, recovery, and infectivity potential. Our results demonstrated the antiparasitic potential of NPs. The findings support the further exploration of NPs as a possible source of alternative and effective anti-T. gondii agents.

収録刊行物

• International Journal of Nanomedicine

  International Journal of Nanomedicine 12 1647-1661, 2017-02

  Dove Medical Press

キーワード

• antiparasite
• drug screening
• nanomedicine
• toxoplasmosis

詳細情報

• CRID: 1050001337584053632
• NII論文ID: 120006391003
• DOI: 10.2147/ijn.s122178
• ISSN: 11782013
• Web Site: https://obihiro.repo.nii.ac.jp/records/1266
• Web Site: https://www.dovepress.com/getfile.php?fileID=35203
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN